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公司荣获CNAS、国家高新技术企业、四川省专精特新中小企业等荣誉
成都乐美天医药科技有限公司荣获CNAS,国家高新技术企业、四川省专精特新中小企业等荣誉
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云连、雅连、味连｜黄连与胡黄连的化学成分与药理活性及其差异
俗话说：“哑巴吃黄连，有苦难言”。中药黄连味极苦，具有清热燥湿、泻火解毒等功效，在糖尿病的治疗方面也具有独特优势。黄连的来源植物相对较多，“味连”、“雅连”、“云连”均在临床上作为黄连使用。除此之外，胡黄连也有“黄连”之称，也常被当作黄连使用。事实上，胡黄连与黄连是两种不同的中药，二者的化学成分和主治功效存在较大的差异。
黄连（左）和胡黄连（右）
The proverbial expression ‘even a mute person can taste the bitterness of the coptis root and suffer in silence’ highlights the intense bitterness associated with coptis root (named Huang-Lian in Chinese), a Chinese herbal medicine renowned for its medicinal properties. This botanical remedy exhibits various therapeutic effects, including heat-clearing, dampness-drying, fire-purging, and detoxification, which render it particularly advantageous in the treatment of diabetes. Coptis root can be obtained from several plant species, such as Wei-Lian, Ya-Lian, and Yun-Lian, all of which are utilized in clinical practice as coptis. Moreover, hu coptis shares the same designation as coptis and is often used interchangeably. Nevertheless, it is important to recognize that hu coptis and coptis root are distinct traditional Chinese medicines, differing significantly in their chemical composition and primary therapeutic effects.
1. 药典收录与性味归经
黄连始载于《神农本草经》，位列上品。2015版《中国药典》规定黄连为毛茛科植物黄连 Coptis chinensis Franch.（味连）、三角叶黄连C. deltoidea C. Y. Cheng et Hsiao（雅连）或云连C. teeta Wall.（云连）的干燥根茎。黄连味苦，性寒；归心、脾、胃、肝、胆、大肠经。
胡黄连名出《新修本草》，为玄参科植物胡黄连Picrorhiza scrophulariiflora Pennell的干燥根茎，味苦，性寒；入肝、胃、大肠经。
1. Pharmacopoeia Inclusion and Categorization
Huang-Lian was originally documented and classified as a top-grade herb in the Chinese ancient book Shen Nong Ben Cao Jing. According to the 2015 edition of Pharmacopoeia of the People's Republic of China, Huang-Lian specifically refers to the dried rhizome and root obtained from plants of the Ranunculaceae family, namely Coptis chinensis Franch. (Wei-Lian), Coptis deltoidea C. Y. Cheng et Hsiao (Ya-Lian), or Coptis teeta Wall. (Yun-Lian). Huang-Lian has a bitter taste and cold nature, and belongs to the meridians of the heart, spleen, stomach, liver, gallbladder and large intestine, according to traditional Chinese medicines. While Hu-Huang-Lian, first mentioned in the materia medica book Xin Xiu Ben Cao, refers to the dried rhizome and root of the plant Picrorhiza scrophulariiflora Pennell of the family Scrophulariaceae, has a bitter taste and cold nature, and belongs to the liver, stomach, and large intestine meridians.
2. 黄连饮片的炮制
黄连秋季采挖，除去须根和泥沙，干燥，撞去残留须根。
黄连味苦，临床上一般使用其炮制品。其炮制方法为：除去杂质，润透后切薄片，晾干，用黄酒、姜汁、醋、吴茱萸或猪胆汁炮制，分别得到酒黄连、姜黄连、醋黄连、萸黄连等。临床上以酒黄连、姜黄连、萸黄连较为常用。
胡黄连的炮制以生切为主。
2. Processing of Huang-Lian Slices
Huang-Lian is harvested during the autumn season. After the removal of adventitious roots and debris, it undergoes a drying process, during which any remaining adventitious roots are knocked off. Huang-Lian possesses a bitter taste, thus its processed products are frequently utilized in clinical applications. The processing procedure involves the elimination of impurities, followed by thin slicing of the herb after moistening and subsequent drying. Then it is subjected to processing with yellow wine, ginger juice, vinegar, Evodia rutaecarpa, or pig bile, resulting in various processed forms such as Jiu- Huang-Lian (wine-processed), Jiang-Huang-Lian (ginger-processed), Cu-Huang-Lian (vinegar-processed), and others. Among these, Jiu-Huang-Lian, Jiang-Huang-Lian and Cu-Huang-Lian are commonly employed in clinical practice. In contrast, Hu-Huang-Lian is primarily used in its raw form.
3. 黄连的化学成分
黄连的化学成分包括生物碱类、木脂素类、黄酮类、有机酸等。生物碱类化合物为黄连的主要药效成分，2015版《中国药典》规定以小檗碱、表小檗碱、黄连碱、巴马汀作为黄连的指标成分进行质量检测。其中，小檗碱（黄连素）含量最高，可高达10%。“味连”、“雅连”、“云连”中小檗碱的含量略有差异，其中“云连”中小檗碱含量最高。相比于“雅连”和“云连”，“味连”中巴马汀、黄连碱、表小檗碱、非洲防己碱含量较高，药根碱含量较低。
现已从黄连中鉴定到的木脂素主要包括(±)-5′-甲氧基松脂素、(±)-松脂醇、 (±)-落叶松树脂醇、(±)-5′-甲氧基落叶松树脂醇、(±)-异落叶松树脂醇、(+) -异落叶松脂素、黄连木脂素A、黄连木脂素B等；黄连中的黄酮类化合物主要包括鼠李素、汉黄芩素3,5,7-三羟基-6,8-二甲基黄酮、2′,4,4′-三羟基-6′-甲氧基二氢查尔酮、7,4′-二羟基-5-甲氧基黄烷酮、6,8-二甲基-3,5,7-三羟基菲酮等；黄连中的有机酸类化合物主要有东莨菪素、原儿茶酸、阿魏酸、绿原酸、邻二苯酚、乳酸、香草酸、龙胆酸等。
胡黄连的化学成分主要包括胡黄连苦苷等环烯醚萜类、葫芦素类和酚苷类化合物，与黄连中的化学成分差异显著。
黄连中的生物碱类化合物骨架
3. Chemical Composition of Huang-Lian
The chemical constituents of Huang-Lian encompass alkaloids, lignans, flavonoids, and organic acids. Alkaloids serve as the primary bioactive constituents of Huang-Lian, and the 2015 edition of Pharmacopoeia of the People's Republic of China designates berberine, epiberberine, coptisine and palmatine as the reference compounds for evaluating the quality of Huang-Lian. Notably, berberine, also known as coptisine, displays the highest concentration, reaching up to 10%. Slight variations in berberine content exist among Wei-Lian, Ya-Lian and Yun-Lian, with Yun-Lian exhibiting the highest content. In comparison to Ya-Lian and Yun-Lian, Wei-Lian demonstrates elevated levels of palmatine, coptisine, epiberberine, and columbamine, while its jatrorrhizine content is relatively lower.
The lignans identified from Huang-Lian include (±)-5'-methoxypinosylvin, (±)-pinosylvinol, (±)-larch resinol, (±)-5'-methoxyresinol of larch, (±)-isoresinol of larch, (+)-isolariciresinol, coptis lignan A, and coptis lignan B. The flavonoids present in Huang-Lian mainly contain taxifolin, 3,5,7-trihydroxy-6,8-dimethylflavone, 2',4,4'-trihydroxy-6'-methoxydihydrochalcone, 7,4'-dihydroxy-5- methoxyflavanone, and 6,8-dimethyl-3,5,7-trihydroxyphenanthrene-1,4-dione. The organic acids identified from Huang-Lian primarily include catechic acid, ferulic acid, chlorogenic acid, resorcinol, lactic acid, vanillic acid, and gentiopicroside.
The chemical constituents of Hu-Huang-Lian primarily include sesquiterpene lactones such as hu coptis glucoside, cucurbitacins, and phenolic glycosides. These compounds exhibit significant differences compared to the chemical constituents found from Huang-Lian.
4. 黄连的药理活性
黄连具有清热燥湿，泻火解毒的传统功效，临床用于主治湿热痞满、呕吐吞酸、泻痢、黄疸、高热神昏、心火亢盛、心烦不寐、心悸不宁、血热吐魈、目赤、牙痛、痈肿 疔疮等症，外用可治湿疹、湿疮、耳道流脓。现代药理学研究表明黄连具有抗菌、消炎、抗肿瘤、抗氧化、调血脂、降血糖、抗心律失常等药理活性。尤为值得注意的是，作为黄连指标成分的小檗碱，同时也是黄连的主要抗菌活性成分，季铵类生物碱的结构特点使其主要以盐酸盐（即盐酸小檗碱，或盐酸黄连素）的形式生产、使用，具有清热燥湿、行气止痛、止痢止泻的药效，抗菌谱广，临床主要用于治疗痢疾、肠炎、眼结膜炎、化脓性中耳炎等，还因其具有阻断α-受体的功能而用于治疗心律失常。
胡黄连具有保肝、利胆、抗炎、保护神经细胞、调节血糖、降血脂等作用，此外对心肌细胞的凋亡具有保护作用。
盐酸小檗碱的化学结构
4. Pharmacological Activities of Huang-Lian
Traditionally, Huang-Lian possesses therapeutic effects of clearing heat, drying dampness, purging fire, and detoxification, and it is used to treat conditions such as damp-heat obstructing the middle burner, vomiting with acid regurgitation, diarrhea, jaundice, high fever with delirium, excessive heart fire, restlessness and insomnia, palpitations and uneasiness, vomiting blood due to heat, red eyes, toothache, abscesses, and boils in clinical practice. Topically, it can be used to treat eczema, moist sores, and purulent discharge from the ear canal. It has been revealed by modern pharmacological studies that Huang-Lian possesses pharmacological activities such as hypoglycemic, antimicrobial, antioxidant, anti-inflammatory, anticancer, regulation of blood lipids, and antiarrhythmic effects.
It is worthy to note that berberine, as an indicator component of Huang-Lian, is also the main antibacterial active ingredient of the title plant. The structural characteristics of quaternary alkaloids make it mainly produced and used in the form of hydrochloride (berberine hydrochloride), which has a wide antimicrobial spectrum, and is mainly used for the treatment of dysentery, enteritis, ocular and conjunctival inflammation, purulent otitis media and so on. It is also used in the treatment of cardiac arrhythmia due to its role in blocking α-receptors.
The activities of Hu-Huang-Lian revealed by modern pharmacology include hepatoprotective, choleretic, anti-inflammatory, neuroprotective, blood sugar-regulating and lipid-lowering. Furthermore, it was discovered that Hu-Huang-Lian exhibit a protective effect against apoptosis in myocardial cells.
总之，黄连与胡黄连在化学成分及药理活性方面均存在明显差异，用途迥异。黄连作为一种重要的中药材，具有清热解毒、抗菌消炎和调节胃肠功能等临床药效，对感染性疾病、消化系统疾病、呼吸系统疾病和肝胆疾病均具显著疗效，应用范围非常广泛，市售以黄连为主要药效成分的中成药有双黄连口服液、黄连双清丸、牛黄上清丸、清胃黄连丸、黄连上清丸、黄连胶囊等。
In conclusion, Huang-Lian and Hu-Huang-Lian differ significantly in their chemical composition and pharmacological activities, resulting in distinct applications. Huang-Lian, as a significant traditional Chinese medicine, exhibits clinical effects including heat-clearing, detoxification, antimicrobial, anti-inflammatory, and regulation of gastrointestinal function. It demonstrates obviously therapeutic efficacy in infectious diseases, digestive disorders, respiratory conditions, and liver and gallbladder ailments. To date, Huang-Lian is widely utilized and can be found in various commercially available Chinese patent medicines, such as Shuang-Huang-Lian oral solution, Huang-Lian-Shuang-Qing pills, Niu-Huang-Shang-Qing pills, Qing-Wei-Huang-Lian pills, Huang-Lian-Shang-Qing pills, and Huang-Lian capsules.
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乐美天产品推荐 | 沉香系列
图为沉香
沉香
Chenxiang
AQUILARIAE LIGNUM RESINATUM
本品为瑞香科植物白木香Aquilaria sinensis （ Lour.） Gilg 含有树脂的木材。全年均可采收，割取含树脂的木材，除去不含树脂的部分，阴干。
性状
本品呈不规则块、片状或盔帽状，有的为小碎块。表面凹凸不平，有刀痕，偶有孔洞，可见黑褐色树脂与黄白色木部相间的斑纹，孔洞及凹窝表面多呈朽木状。质较坚实，断面刺状。气芳香，味苦。
性味与归经
辛、苦,微温。归脾、胃、肾经。
功能与主治
行气止痛，温中止呕，纳气平喘。用于胸腹胀闷疼痛，胃寒呕吐呃逆，肾虚气逆喘急。
含量测定
本品每 1g 含沉香四醇（C17H18O6）应为 15.0mg~75.0mg
图为沉香
中药配方颗粒省级药品标准-沉香
药理研究
从国产沉香中分离得到 246 种化合物，包括单萜、倍半萜、二萜、三萜、甾醇、黄酮、色酮、酚酸和脂肪族化合物，其中作为沉香主要成分的倍半萜和色酮类化合物的数目分别占 25.6%和 52.0%。
研究人员在浓氨水致咳实验中发现，采用沉香醇提物灌胃治疗的小鼠 2 min 内的咳嗽次数明显减少，咳嗽潜伏期也明显延长；在磷酸组胺致哮喘实验中，采用沉香醇提物灌胃治疗的小鼠哮喘潜伏期显著延长。这两项实验表明沉香醇提物具有止咳平喘功效。
成都乐美天医药致力于天然产物分离纯化与鉴定工作，目前已分离沉香活性成分10种，欢迎留言咨询。
参考文献：
【1】中国药典. 第一部[S]. 2015.
【2】彭德乾，王灿红，刘洋洋，等 . 沉香的化学成分及其药理活性 的研究进展［J］.中国现代应用药学，2021，38（3）：358-365.
【3】董梅月，杨中一，马 祯，等 . 国产沉香化学成分及药理作用研究进展［J］.山东中医杂志，2020，39（2）：189-194.
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以假乱真！真假酸枣仁及其化学成分差异
How to Make an Accurate Determination? The Chemical Differences between Ziziphi Spinosae Semen and Ziziphi Mauritianae Semen Are Significant.
作为中药治疗失眠的首选药物，酸枣仁已有两千多年的临床使用历史，其道地药材产地在我国华北地区；理枣仁为近现代用药，主要分布在我国西南地区。近年来，由于二者性状特征相近，功效相似，但市场价格差异较大，从而导致理枣仁（甚至枳椇子、染色扁豆）冒充或掺伪酸枣仁的现象较为普遍，在中药材市场及临床应用中较为混乱。
As the first choice of traditional Chinese medicine for the treatment of insomnia, Ziziphi Spinosae Semen (ZSS) has a clinical history of over 2,000 years, and its authentic medicinal materials are produced in the northern region of China. In contrast, Ziziphi Mauritianae Semen (ZMS) is a modern medicine mainly distributed in the southwestern region of China. In recent years, due to the similar morphological characteristics and therapeutic effects of the two herbs, but a significant difference in market prices, it has become increasingly common for ZMS to be fraudulently labeled or adulterated as ZSS, leading to confusion in the Chinese herbal medicine market and clinical applications.
那么，二者究竟有何特点？如何准确区分酸枣仁和理枣仁呢？
What are the characteristics that distinguish ZSS from ZMS, and how can they be accurately distinguished?
1 药典收录与性味归经
酸枣仁 （Ziziphi Spinosae Semen，ZSS）为鼠李科枣属植物酸枣 Z. jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow的干燥成熟种子，始载于《神农本草经》，位列上品，历代本草皆有收录。其味甘、酸，性平，归肝、胆、心经，具有养心补肝、宁心安神、敛汗、生津之功效。作为中药治疗失眠的首选药物，酸枣仁在治疗失眠相关的药方中使用率高达70%以上。
理枣仁 （Ziziphi Mauritianae Semen，ZMS）为酸枣仁同科同属植物滇刺枣 Z. mauritiana Lam. 的干燥成熟种子，也称“滇枣仁”、“缅枣仁”或“进口酸枣仁”等，为近现代用药，仅在《滇南本草》中有过收录。其味甘、平，归心、肝经，具有宁心安神，除烦敛汗的功效。在云南民间被作为治疗失眠的习用药材使用。
1 Pharmacopoeia Inclusion and Categorization
ZSS, also known as sour jujube seed, is the dried mature seed of the plant Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow, which belongs to the Rhamnaceae family. It was first recorded in the classic Chinese herbal book "Shennong Bencao Jing" and was listed as a top-grade herb. It has been included in nearly all Chinese pharmacopoeias throughout history. ZSS is associated with the liver, gallbladder, and heart meridians，possess the effects of nourishing the heart and liver, calming the mind and tranquilizing the nerves, according to the theory of Traditional Chinese Medicines. As the first choice for treating insomnia in Traditional Chinese Medicines, ZSS is used in over 70% of insomnia-related prescriptions.
ZMS, also known as "Dian zao ren", "Mian zao ren", or "imported sour jujube kernel", is the dried mature seed of Ziziphi mauritiana Lam., a plant belonging to the same family and genus as ZSS, but a different species. It is a relatively modern medicinal material and has only been recorded in the "Dian Nan Ben Cao". ZMS is associated with the heart and liver meridians, and is known for its calming and sweat-reducing effects, according to TCMs. ZMS is commonly used in Yunnan folk medicine to treat insomnia.
2 真假酸枣仁的化学成分差异
现代药理学研究表明，酸枣仁和理枣仁均富含三萜皂苷、黄酮、生物碱和核苷类化学成分，但所含化合物的种类和含量差异明显。
2 Chemical Differences between ZSS and ZMS
It has been discovered by modern pharmacological research that both ZSS and ZMS are rich in triterpenoids, flavonoids, alkaloids, and nucleoside. However, there are also significant differences in the types and contents of these compounds between ZSS and ZMS.
2.1 三萜皂苷
酸枣仁和理枣仁所含三萜皂苷类成分差异较大，酸枣仁中皂苷类成分的种类和数量均明显多于理枣仁。研究表明，酸枣仁中总皂苷含量约为 0.09%，而理枣仁中总皂苷含量约为0.04%。其中，以酸枣仁皂苷 A为代表的达玛烷型四环三萜是酸枣仁中含量最多的一类三萜皂苷，酸枣仁皂苷 A和酸枣仁皂苷 B一般被认为酸枣仁的特征成分。而理枣仁的特征成分是白桦酯醛，理枣仁中一般检测不到酸枣仁皂苷 A，酸枣仁皂苷 B的含量也低于酸枣仁。
2.1 Triterpenoids
There is a significant difference in the triterpenoids between ZSS and ZMS. The variety and content of saponins in ZSS are significantly higher than those in ZMS. It is revealed that the total saponins in ZSS is approximately 0.09%, while that in ZMS is approximately 0.04%. Among them, dammarane-type tetracyclic triterpenoids, represented by jujuboside A (JuA), are the most abundant type of triterpenoids in ZSS. JuA and jujuboside B (JuB) are also generally considered to be the characteristic components of ZSS. The characteristic component of ZMS is betulinic aldehyde, and JuA is not detected in ZMS, while the content of JuB is lower than that in ZSS.
2.2 黄酮类化合物
酸枣仁中总黄酮含量约为 0.95%，黄酮类成分的结构类型相对丰富，但其总含量明显低于理枣仁。以芫花素C-6碳苷为骨架的斯皮诺素（spinosin）及其衍生物，为酸枣仁和理枣仁共同的特征类黄酮化合物。据文献报道，酸枣仁中斯皮诺素、6′′′-芥子酰斯皮诺素、6′′′-阿魏酰斯皮诺素等黄酮类化合物的含量均显著低于理枣仁。
2.2 Flavonoids
With more skeleton types of flavonoids in ZSS, the content of total flavonoids in ZSS is about 0.95%, which is significantly lower than that in ZMS. Spinosin and its derivatives, which have a skeleton of glycoside located at C-6 site of apigenin with a carbon atom, are common flavonoids in ZSS and ZMS. As reported in the literatures, the content of flavonoids such as spinosin, 6′′′-sinapoyl spinosin, and 6′′′-feruloyl spinosin in ZSS are all significantly lower than that in ZMS.
2.3 生物碱类化合物
酸枣仁生物碱主要包含异喹啉类生物碱、阿朴菲类生物碱和环肽类生物碱，其中，异喹啉类生物碱含量相对较高；理枣仁中的生物碱主要为环肽类生物碱。酸枣仁中木兰花碱的含量约为理枣仁的 2 倍，乌药碱、酸李碱和莲心季铵碱的含量也明显高于理枣仁。
2.3 Alkaloids
The main alkaloids in ZSS include isoquinoline alkaloids, aporphine alkaloids, and cyclic peptide alkaloids. Among them, the content of isoquinoline alkaloids is higher. In contrast, alkaloids forming as cyclic peptide alkaloids are the main alkaloids in ZMS. The content of magnoflorine in ZSS is about twice that of ZMS. The content of coclaurine, zizyphusine, and lotusine are also significantly higher in ZSS compared to ZMS, respectively.
2.4 氨基酸和核苷
酸枣仁和理枣仁均含有丰富的氨基酸。迄今，酸枣仁中已检测到 22 种氨基酸，理枣仁中已检测到 19 种氨基酸。酸枣仁中必须氨基酸的总含量约为理枣仁的 8 倍。酸枣仁中精氨酸、天冬酰胺、丝氨酸和酪氨酸等氨基酸含量较高，约占总氨基酸含量的50%，而理枣仁中精氨酸和丝氨酸含量较高。理枣仁中缬氨酸和蛋氨酸含量明显高于酸枣仁。
此外，酸枣仁中核苷的种类及含量均多于理枣仁，特别是腺苷、尿苷和腺嘌呤等核苷含量较高，占总核酸和碱基含量的 60%以上。
2.4 Amino Acids and Nucleoside
The content of amino acids in both ZSS and ZMS are rich. To date, 22 types of amino acids have been detected in ZSS and 19 types have been detected in ZMS. The total content of essential amino acids in ZSS is approximately eight times higher than those in ZMS. Arginine, asparagine, serine, and tyrosine are richer in ZSS, accounting for about 50% of the total amino acid content, while the content of arginine and serine are higher in ZMS. However, the contents of methionine and lysine in ZMS are significantly higher than those in ZSS.
In addition, the types and content of nucleosides in ZSS are higher than those in ZMS, especially adenosine, uridine, and adenine, which account for more than 60% of the total nucleic acid and base.
综上，真假酸枣仁的化学成分存在明显差异，可以通过现代检测技术快速鉴别。酸枣仁的真伪及质量的准确甄别，有助于维护市场秩序，有助于维护消费者的合法权益，有助于中药产业的健康发展。
In conclusion, there are significant chemical differences between ZSS and ZMS, which can be quickly and accurately identified by modern detection technology. It is very important and urgent to accurately distinguish the authenticity and quality of ZSS，which is crucial to maintain normal market order, safeguard the legitimate rights and interests of consumers, and ensure the healthy development of the traditional Chinese medicine industry.
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海外展会 | 乐美天受邀参加 CPHI Japan 2023
海外展会 | 乐美天受邀参加 CPHI Japan 2023
CPhI Japan 2023
2023年4月19日至21日，世界制药原料日本展会（CPhI Japan）在日本·东京有明国际展览中心 (Tokyo Big Sight)举办。该展会自2002年起每年举办一届，已成为全球医药原料系列展览之一，并发展成为日本最大的专业性国际制药展览会。
与全球医药企业共同探索
乐美天受邀参加CPHI Japan展会
成都乐美天医药科技有限公司，作为专业从事中药（植物药）物质基础研究及天然化合物纯化分离、中药化学对照品实物供应的科技型技术服务企业，应邀参加本次展会。展会期间，乐美天参展同事积极与各国医药企业交流合作，展示了专业方面的研究成果和技术实力。
此次展会为乐美天提供了一个宝贵的机会，向全球医药企业展示技术和产品优势，同时也为乐美天未来的发展提供了更多的合作机会和可能性。乐美天将继续秉持着“民族品牌 国际视野”的企业愿景，坚持自主创新和技术研发，不断推动中药行业的发展和创新，为客户提供更优质的服务和产品。
关于乐美天
成都乐美天医药科技有限公司是一家专业从事中药（植物药）物质基础研究及天然化合物纯化分离、中药化学对照品实物供应的科技型技术服务企业,公司位于成都市温江科技园区,集研发、生产 、销售于一体,经营面积6000余平方米,其中分离纯化实验室1800平,合成实验室1200平,CNAS检测中心1000平，为客户在药品、食品、化妆品、日化用品等相关领域提供整体解决方案，公司致力于打造中国最高效的药物分离纯化及药品标准研究服务平台。
截至到2022年4月，乐美天研制天然产物化合物达到4000多种，其中近350种(还在陆续增加)依据国家标准物质相关技术要求进行标定，提供准确的含量值,完全满足各个科研单位，高等院校，医药企业的日常检测工作要求。确保分析检测结果的准确性。
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“兔”飞猛进·共攀新峰 | 乐美天2022年终总结暨优秀员工表彰大会圆满落幕
日月其迈，时盛岁新。
忙碌而不平凡的2022年已经落下帷幕
回望乐美天的2022年，
每一个奋斗足迹都令人难忘
每一个高光时刻都弥足珍贵。
1月13日，乐美天召开年终总结大会。
总结过往，展望未来，
为2022年的工作画上圆满的句号。
会议概况
2023年1月13日13:00点，乐美天2022年年终会议、优秀员工表彰大会暨2023年一季度员工生日会在二楼大会议室召开。本次会议旨在总结回顾2022年，总结经验，发现不足，更好地布局2023年工作计划。会议由行政部雷俊主持，董事长朱海洋，总经理张光兰女士，副总经理陈冲，各部门管理层及全体员工参加本次会议。
部门负责人发言
会上，乐美天各部门负责人作2022年度工作总结报告。全面梳理总结2022年工作，对重点工作开展情况进行汇报，并分析过去一年取得的成绩及存在的主要问题，为2023年工作的开展明确了方向、目标。
副总经理陈冲发言
副总经理陈冲就2023年的工作计划进行了全面部署，陈总表示2023年公司将围绕着务实而不浮夸，简洁而不简单来开展工作,而后对各部门的工作开展进行了详细安排。
一、市场部：围绕以客户为中心的方针，简化工作流程；
二、采购部：拓宽外部资源渠道，提高工作效率；
三、研发部：加强日常安全管理；产品高质、高量、高效产出；提升专业技 能；做好时间、空间、项目等衔接工作；
四、质检部：推进落实CNAS建设；加强基础数据与报告的审核；严格执行实验室操作规程。
总经理张光兰发言
新的一年开启新的希望，新的一年承载新的梦想。总经理张光兰回顾了2022年大家共克难关的点滴历程，对在困难重重下坚持岗位职责的各位乐美天家人表达了肯定与感谢，同时对2022年的工作开展进行了总结与反思。对于已经到来的2023，张总做了以下安排：
一、坚持夯实打造全球较大较全的天然产物化合物库的基本盘；
二、用心服务客户，成就客户，陪伴客户共同成长；
三、打造学习型团队，实现内在成长；
四、做品高价优的产品，提高交付效率。
董事长朱海洋发言
最后董事长朱海洋总结了2023年对大家的期望 。
加强危机意识
以客户的需求为唯一价值导向
提升自我，迎接挑战
奋斗永无止境，此次是一次定标明向、明确责任的落实会，更是一次凝心聚力、砥砺奋进的动员会。面对新的征程和挑战，面对新的困难和机遇，乐美天必将不忘初心，坚持以客户需求为工作导向，以饱满的激情开启2023新篇章！
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