Isochlorogenic acid C (ICAC) is found in a variety of natural foods and medicinal plant materials. This study aims to validate the biological activity of isochlorogenic acid C in limiting inflammation by the Erk/JNK/NF-κB pathway. In this study, TNF-α-induced human fibroblast-like synoviocytes and collagen-induced arthritis animal models were used to perceive the potential anti-inflammation mechanism of ICAC. The role of isochlorogenic acid C was evaluated by observing the migration, invasion ability, and apoptotic activity of TNF-α-induced fibroblast-like synoviocytes cells in humans and analysing foot swelling, joint index, and histopathological changes in a collagen-induced RA animal model. The results reveal that ICAC inhibited the proliferation of human fibroblast-like synoviocytes and promoted their apoptosis. ICAC also blocked the nuclear transfer of NF-κB, Erk, and JNK. It was observed that ICAC significantly inhibited the degree of posterior foot swelling in CIA, reducing arthritis scores, bone tissue injury, and articular synovitis. ICAC may promote cell apoptosis and inhibit the hyperactivation of inflammatory cells to alleviate inflammation-induced synovial proliferation through the Erk/JNK/NF-κB pathway.
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Isochlorogenic acid C (ICAC), with a purity of 98%, was purchased from Desite Biotechnology Co., Ltd. (Lot: 1092320232, Chengdu, China).……
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原文地址:https://doi.org/10.1155/2023/5547108
Royal society of chemistry-12 Mar 2020
The development and
World Journal of Microbiology and Biotechnology-20 June 2018
期刊名:World Journal of
Nat Biotech| 北京大学谢正伟课题组与合作者创建基于基因指纹和深度学习的药效预测系统(DLEPS)
原文链接:htt
Journal of separation science-26 November 2019
Biosurfactant trehal
Journal of separation science-07 January 2020
Comparison of the ac
细辛水提物HPLC指纹图谱及化学模式识别的研究
摘要:[目的] 通过建立中药细辛水提物高